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KT5720
KT5720 is a potent, cell permeable inhibitor of PKA, and is a valuable tool in studies delineating cAMP-dependent signaling pathways, including activation of the transcription factor CREB. Inhibition of PKC, PKG, and MLCK is negligible. KT5720 is prepared by a chemical modification of K-252a.
KT5720 is a hexylester derivative of K-252a and is a selective inhibitor of PKA (Ki=0.056 µM)
KT5720 inhibits catalytic subunit of PKA
It is a cell-permeable, selective inhibitor of cAMP-dependent protein kinase (PKA; IC50=56nM). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK), was observed. KT5720 was used to examine the role of PKA in various cellular events such as cell adhesion, neurite branching, anterograde axonal transport, memory consolidation, and regulation of transcription by cyclic AMP-dependent response element-binding protein
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